C&EN

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

Biodegradable polymers are largely employed in the biomedical field, ranging from tissue regeneration to drug/vaccine delivery. The biodegradable polymers are highly biocompatible and possess ...
C&EN

AbEgDiffuser: Antibody Sequence-Structure Codesign with Equivariant Graph Neural Networks and Diffusion Models

School of Information and Electronics, Beijing Institute of Technology, Beijing 100081, China ...
C&EN

Chemotherapeutic Spherical Nucleic Acids

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States ...
C&EN

A Metal–Phenolic Network-Coated Coacervate System Mediates Mitochondrial Modulation and Bone Homeostasis Restoration for Postmenopausal Osteoporosis Therapy

Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials Ministry of ...
C&EN

Skeletal Editing of Quinolines by Single-Atom Carbon Insertion–Deletion

Shanghai Frontiers Science Center for Drug Target Identification and Delivery, Laboratory of Innovative Immunotherapy, and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of ...
C&EN

A Deep Learning-Based Framework for Valence Bond Structure Selection and Weight Prediction

State Key Laboratory of Physical Chemistry of Solid Surfaces, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, and College of Chemistry and Chemical Engineering, Xiamen ...
C&EN

“De Novo” Construction of Planar-Chiral Ferrocenes via Palladium/Chiral Norbornene Cooperative Catalysis

Engineering Research Center of Organosilicon Compounds and Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric OptoElectronic Materials, College of Chemistry and Molecular ...
C&EN

Modular Nanoassemblies Mimicking p62 Aggregates for Targeted Organelle Sequestration and Degradation against Breast Cancer

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant Sourced Drug and Sichuan Research Center for Drug ...
C&EN

Postbiotics as an Innovative Intervention Strategy for Ulcerative Colitis: Insights into Bioactive Components and Mechanisms of Action

College of Food Science and Technology, Henan University of Technology, Zhengzhou, Henan 450001, China ...
C&EN

Discovery of Fluoroalkenes as Dual Inhibitors of Diacylglycerol Kinases Alpha and Zeta (DGKα/ζ)

Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States ...
C&EN

A Novel Marine Bacterium-Derived Heparinase with High Potential for the Structure–Function Studies of Heparin/Heparan Sulfate

National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao 266237, China School of Life Science and Technology, ...
C&EN

A General Metallaphotoredox Platform for N-Alkylated Sulfoximines as Bioisosteric Building Blocks

Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States ...