ABSTRACT: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a promising class of medications for type 2 diabetes mellitus (DM2) treatment. This study aims to evaluate the clinical efficacy, ...

Credit: Getty Images New data presented at Kidney Week 2024 expand what is known about the beneficial effects of SGLT2 inhibitors and GLP-1 receptor agonists in patients with chronic kidney disease.

Our research is focused on the role of ion channels in the physiology and pathophysiology of epithelial cells, particularly intestinal and airway cells. In collaboration with R Muimo (Medical School) ...

Clinicians should consider incorporating sodium-glucose cotransport 2 inhibitors into the management of acute kidney disease and type 2 diabetes, according to investigators. Sodium-glucose cotransport ...

ABSTRACT: The electrogenic Na+-HCO3– cotransporter NBCe1 encoded by SLC4A4 gene plays essential roles in the regulation of intracellular/extracellular pH. Three ...

SGLT2 inhibitors are one of many medicines you may take to treat type 2 diabetes. They also can protect your kidneys and make heart failure less likely. (Photo Credit: Moment RF/Getty Images) SGLT2 ...

Maurice Benjamin “Moe” Burg, who revolutionized our understanding of kidney physiology through his invention and exploitation of a technique for microdissection and study of isolated nephron segments, ...

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom Historically, comparative red cell research has provided an important resource for study. The behaviour of red ...

Department of Cardiovascular Surgery, Dalian Municipal Central Hospital, Dalian, China Background: The efficacy of dapagliflozin and empagliflozin in sodium-glucose cotransport-2 inhibitors (SGLT-2i) ...

Here we report two cryoelectron microscopy (cryo-EM) structures that represent human KCC1 trapped in an inward-open state or arrested in its elusive outward-open state by the KCCs inhibitor VU0463271 ...

CCCs in mammals include the potassium-chloride cotransporters KCC1-4, the sodium-potassium-chloride cotransporters NKCC1-2, the sodium-chloride cotransporter NCC, and CCC8-9 (Figure 2—figure ...