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NFL, San Francisco 49ers and Titans

49ers vs Colts picks, predictions, odds for NFL Week 16 game Monday

The San Francisco 49ers and Indianapolis Colts play on Monday, Dec. 22, at the Colts' Lucas Oil Stadium in a game on the NFL Week 16 schedule.

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49ers vs. Titans: Where to watch NFL Week 15, betting odds, score prediction, sportsbook promos, SGP picks

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What channel is 49ers vs Titans NFL game today? Start time, schedule, where to watch, streaming

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Titans vs 49ers box score, player stats, game stats, score summary

The Tennessee Titans earned a 37-24 loss to the San Francisco 49ers on Dec. 14 at Levi's Stadium.

Niners Wire · 19h

Best photos from 49ers vs. Titans in Week 15

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Titans' losing ways return as Cam Ward can't keep up with high-flying 49ers

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Titans' Jeffery Simmons records a sack, forced fumble and a TD catch in loss to 49ers

Simmons put together the sixth game on record with at least one sack, a forced fumble and a touchdown catch as the do-everything defensive tackle showed off his wide array of skills.

Niners Wire · 1d

How to watch 49ers aim to put tighter grip on playoff spot vs. Titans

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Where 49ers sit in 2025 NFL Week 16 power rankings after win vs. Titans

Rounding up Bears Week 16 NFL power rankings

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NFL power rankings: Rams reclaim No. 1 from Broncos; Bills, 49ers rise as Packers fade for Week 16

Week 15 in the NFL had its share of heavyweight matchups and playoff knockouts.

USA TODAY Touchdown Wire on MSN · 20h

NFL power rankings week 16: New No. 1 after Patriots, Pack fail tests

· 13h · on MSN

NFL power rankings week 16 see Rams, Seahawks, Broncos make No. 1 case

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NFL power rankings Week 16: New No. 1 after Patriots, Pack fail tests

Week 15 of the NFL season felt very top heavy, with several teams considered the cream of the crop had a chance to exhale a bit against overmatched opponents.

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Bears report card: Team grades in NFL Week 15 win over Browns

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Final Score: Chargers defeat Chiefs 16-13 in NFL Week 15

8hon MSN

Stanford Legends Show Out For Rams, 49ers as NFL Playoffs Near

The NFL playoff race is heating up. With only a few weeks left in the regular season, the race for playoff positioning is heating up, with multiple teams fighti

14h

Philip Rivers to Start vs. 49ers, What Are Colts' Odds of Making NFL Playoff Bracket?

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran quarterback Philip Rivers will get his chance at redemption.

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49ers' Ricky Pearsall faces new injury setback after standout performance in win vs. Titans

San Francisco 49ers quarterback Brock Purdy (13) runs the ball past Tennessee Titans linebacker Cedric Gray, left, during the second half of an NFL football game, Sunday, Dec. 14, 2025, in Santa Clara, Calif. Credit: AP/Godofredo A. Vásquez

Sporting News

NFL picks, predictions against the spread Week 16: Lions stop Steelers, Packers pop Bears, 49ers top Colts

In Sporting News' Week 16 picks against the spread, Detroit and Green Bay rebound from tough losses while the Chargers, Broncos and Chiefs all win in the AFC West.

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NFL injury report, update: San Francisco 49ers vs Indianapolis Colts for NFL Week 16

The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

2don MSN

NFL Insiders Reveal 49ers’ Massive Decision on Brandon Aiyuk

The San Francisco 49ers made a significant decision on wide receiver Brandon Aiyuk that could spell the end of his tenure in the Bay Area.

1don MSN

NFL playoff picture: What 49ers’ win over Titans means for NFC standings

The 49ers face the Titans at home in Santa Clara in Week 15. We break down what the game means for the NFL playoff picture.

49ers' Brock Purdy throws one-yard TD to George Kittle, extending lead over Titans | NFL Highlights

Brock Purdy threw a one-yard TD to George Kittle that extended the San Francisco 49ers lead to 31-10 over the Tennessee Titans.

Colts Wire on MSN

Shane Steichen confirms Colts starting quarterback v. 49ers in Week 16

Indianapolis Colts' head coach Shane Steichen confirmed on Monday that Phillip Rivers will start in next week's game against the San Francisco 49ers on Monday Night football. This announcement by Steichen doesn't come as a surprise. In Rivers' return to action against Seattle, he provided needed stability at the quarterback position.