Joe Burrow could potentially get the green light to square off against Lamar Jackson in an AFC Thanksgiving night showdown.

As always on Thanksgiving, the Lions and Cowboys are hosting the afternoon games. The Ravens are hosting the nightcap this year.

Having teams that annually play on Thanksgiving like the Lions and Cowboys, as well as teams that make rare appearances, gives you several options with NFL DFS picks and a daily Fantasy football strategy.

Week 13 of the 2025 NFL season will be filled with marquee matchups that will start with Thanksgiving Day and a game between the Green Bay Packers and Detroit Lions.

From star performances to unforgettable blunders, here are 10 iconic NFL moments that happened on Thanksgiving.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 on a 49-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

There will be three NFL games on Thanksgiving Day 2025, Nov. 27, but the Arizona Cardinals are not one of the six teams scheduled to play. Instead, the Cardinals will play their Week 13 game against the Tampa Bay Buccaneers on Sunday, Nov. 30, at 11 a.m. MST.