Preview the Kansas City Chiefs' NFL Week 12 matchup with the Colts, including live stream, TV channel, odds, and game information.

Indianapolis Colts running back Jonathan Taylor, an NFL MVP candidate, is playing on a three-year, $42 million contract extension that expires after the 2026 season, per Over the Cap.

A 28-24 Chiefs win is the prediction from the Arizona Republic’s Jeremy Cluff. He wrote: “The Chiefs are a much better team at home (4-1) than on the road (1-4). This is a must-win game for Kansas City against an Indianapolis team coming off a bye. Patrick Mahomes and company will get it done.”

The Indianapolis Colts announced they have officially activated cornerback Charvarius Ward Sr. from injured reserve after the starter missed four games due to a concussion. The team also announced that they have waived cornerback Cameron Mitchell.

DeForest Buckner is also eligible to return from IR in Week 15. With seven games left in the season, the Colts' remaining strength of schedule is one of the more difficult in the NFL. This week, the Colts are on the road, taking on the 5-5 Kansas City Chiefs, who are No. 13 in ESPN's rankings.

Where the Indianapolis Colts stand as they enter a challenging closing stretch to the NFL season: Power rankings, playoff picture.

The latest roster move from the Indianapolis Colts spells bad news for Patrick Mahomes and the Kansas City Chiefs.

The Indianapolis Colts have the fourth-best odds to win Super Bowl LX at +900, trailing only the Los Angeles Rams and Philadelphia Eagles — and they sit as the outright favorite to win the AFC at +400,