You've seen the model's best bets for Indianapolis Colts vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.

Taylor leads the league in rushing yards and total touchdowns in a season reminiscent of LaDainian Tomlinson's incredible 2006 campaign. With fresh legs after a week of rest, Taylor should be ready to run over the Chiefs' front seven.

The Colts are getting healthier at the right time, and it’s just ahead of a key AFC road clash against the Kansas City Chiefs!

Oct 5, 2025; Indianapolis, Indiana, USA; Indianapolis Colts safety Cam Bynum (0) high fives cornerback Charvarius Ward (7) after an interception against the Las Vegas Raiders during the second quarter at Lucas Oil Stadium. / Trevor Ruszkowski-Imagn Images

"We're in a place right now where we understand the sense of urgency…I will make it loud and clear, there's no other people or players around that I'd rather be around to do this thing the right way," offensive coordinator Matt Nagy told reporters on Thursday.

Indianapolis Colts coach Shane Steichen highlights the unpredictable nature of the NFL, where any team can win on any given day.