The Kansas City Chiefs will take on the Indianapolis Colts in Week 12 of the 2025 NFL season. Find out how to watch, listen, and stream.

The Indianapolis Colts' defense is good, but there are still key needs. These are remedied in an early NFL mock draft.

"The Colts appear focused on this season rather than locking up these players mid-season for years to come, according to multiple sources," wrote Jones. "It makes sense on several levels, including not fraying any nerves when talking about value during what is clearly a special season."

The Kansas City Chiefs (5-5) have nine players listed on their injury report as they ready to meet the Indianapolis Colts (8-2) on Sunday, Nov. 23 at GEHA Field at Arrowhead Stadium, with kickoff scheduled for 1 p.m. ET.

Buckner, 31, was having another strong year anchoring the Colts defense with 42 tackles, four sacks and nine tackles for loss in nine games.

You've seen the model's best bets for Indianapolis Colts vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.

Tough test for the Kansas City Chiefs in Week 12. They face one of the best teams in the league, as the Indianapolis Colts are the leaders of the AFC South and are shaping up to be

A 28-24 Chiefs win is the prediction from the Arizona Republic’s Jeremy Cluff. He wrote: “The Chiefs are a much better team at home (4-1) than on the road (1-4). This is a must-win game for Kansas City against an Indianapolis team coming off a bye. Patrick Mahomes and company will get it done.”

The Colts are getting healthier at the right time, and it’s just ahead of a key AFC road clash against the Kansas City Chiefs!