Treatment with the interleukin-36 inhibitor spesolimab was associated with improved lesion clearance vs placebo after one week, but also a greater incidence of infection and systemic drug reactions.

Background Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in ...

Localized pustular psoriasis is a term that refers to a limited area of small pus-filled blisters on your skin, typically on your hands or feet. It is distinct from generalized pustular psoriasis (GPP ...

An international consensus statement on generalized pustular psoriasis (GPP) from the International Psoriasis Council (IPC) includes the recommendation that considerations such as body surface area ...

Psoriasis can involve any area of the skin. The most common areas are those that are prone to significant trauma from rubbing or scratching. These areas include the elbows, knees and scalp. However, ...

You’ve probably heard of psoriasis—the chronic inflammatory condition that can cause itchy, scaly patches on your skin. Less well-known is a rare form of the disease called pustular psoriasis, which ...

Recently, I had a patient with a germline loss-of-function mutation in the interleukin-36 receptor antagonist gene present to my clinic with a rapidly progressive generalized pustular psoriasis (GPP) ...

Stress, infections, and corticosteroid withdrawal are known triggers of generalized pustular psoriasis (GPP). However, doctors cannot attribute every GPP flare to a specific cause. Psoriasis is an ...

GPP can be triggered by the initiation and withdrawal of various medications, in particular the withdrawal of corticosteroids, and by infections, stress, and other conditions. 1,5,6,10 Patients with a ...

Acute generalized exanthematous pustulosis (AGEP) is a rare adverse skin reaction usually caused by medication or acute infection. As numerous diseases may present with pustular eruptions, it is ...

Confused between eczema and psoriasis? Experts explain how these skin conditions differ in symptoms, causes, and treatment.