Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid ...

Opioids remain the most potent and effective pain relievers in medicine, but they’re also among the most addictive drugs that can halt a person’s ability to breathe during an overdose — which can be ...

Neuropeptide FF (NPFF) is an endogenous peptide that plays a critical role in modulating opioid receptor function. Its dual capacity to influence both opioid-induced analgesia and tolerance has ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Opioid drugs such as morphine and fentanyl are like the two-faced Roman god Janus: The kindly face delivers pain relief to millions of sufferers, while the grim face drives an opioid abuse and ...

LA County health officials are inspecting gas stations and smoke shops for kratom and more potent synthetic versions that are ...

Brandy Schillace’s review of “Candace Pert” by Pamela Rykman (Bookshelf, Nov. 15) contains a questionable conclusion: the discovery of the mu opioid receptor in 1972 “helped launch the opioid crisis” ...

TuHURA Biosciences, Inc. (NASDAQ: HURA) ("TuHURA"), a Phase 3 immune-oncology company developing novel technologies to ...