In 2025, Walgreens will once again close on Thanksgiving, with the exception of its 24-hour locations, which will remain open to serve customers. Stores will reopen on Friday morning, Nov. 28, during normal business hours.

What about CVS? According to USA Today, CVS pharmacies will be open on Thanksgiving Day, although possibly with reduced hours. Stores like Walmart, Costco, Target, and Home Depot are closed on Thanksgiving Day 2025, the newspaper noted. The Smithsonian

The retailer is expanding its partnership with pharmacy schools with the launch of a new program, the Walgreens Community Practice Shared Faculty Program.

The company is expanding the number of retail stores served by its micro-fulfillment centers, which use robots to fill thousands of prescriptions for patients who take medications to manage or treat diabetes, high blood pressure and other conditions.

Fruth Pharmacy, a small chain with 12 locations in West Virginia, announced that it will sell its business to Walgreens, ending more than 70 years of service. The retailer has struggled with reduced reimbursement rates from Pharmacy Benefit Managers (PBMs), which contributed to the sale.

If you expect to need a prescription refill around the holidays, or a bout of sniffles has you wondering if you'll need to grab some over-the-counter supplies, these are the major pharmaceutical chains' hours for Thanksgiving.