Scientists now have a better picture of how voltage-gated sodium (Na v) channels interact with certain animal toxins, thanks to structures solved with cryo-electron microscopy. These channels are ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.

The transport of ions is essential to maintain electrophysiological balance on either side of the membrane, called osmotic balance, which is needed for signals to be transduced from their chemical ...

The BACE protease (β-site APP cleaving enzyme) is elevated in the brains of people with Alzheimer disease and takes at least part of the blame for amyloid overload because of its role in the ...

Heterogeneity of Kras status in primary colorectal cancer and corresponding liver metastases.

Metrion Biosciences, today announced the launch of its validated, high-throughput NaV1.9 screening assay to advance discovery and development of novel pain therapeutics. Validated drug discovery assay ...

Nat Clin Pract Neurol. 2008;4(3):159-169. Drug Primary clinical use Protective effect during administration in animal models? Effects of withdrawal in EAE Clinical study Phenytoin Treatment of ...