Nature

TRH-Receptor-Type-2-Deficient Mice are Euthyroid and Exhibit Increased Depression and Reduced Anxiety Phenotypes

Thyrotropin-releasing hormone (TRH) is a neuropeptide that initiates its effects in mice by interacting with two G-protein-coupled receptors, TRH receptor type 1 (TRH-R1) and TRH receptor type 2 ...
Daily Emerald

Thyrotropin (TRH) Peptide: A Multidisciplinary Approach to its Research Implications

Thyrotropin-releasing hormone (TRH) is a small yet highly significant tripeptide consisting of the amino acids pyroglutamate, histidine, and proline. First identified in the hypothalamus, TRH was ...
Nature

CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid

In the central nervous system (CNS), thyrotropin-releasing hormone (TRH) has an important role in regulating energy balance. We previously showed that dietary deprivation of leucine in mice increases ...
The New England Journal of Medicine

A Family with Complete Resistance to Thyrotropin-Releasing Hormone

We report on a family with recessive resistance to the action of thyrotropin-releasing hormone (TRH) due to a nonsense homozygous mutation in the TRH receptor (TRHR) gene (p.R17X). We examined the in ...