BOSTON--(BUSINESS WIRE)--Karuna Pharmaceuticals, focused on targeting muscarinic receptors for the treatment of disorders marked by psychosis and cognitive impairment, today announced the completion ...
Cocaine use can quickly escalate into cocaine use disorder, primarily driven by surges in dopamine from the ventral tegmental area to the nucleus accumbens (NAc). While dopamine-targeted treatments ...
Trial to study positive, negative, and cognitive domains of Schizophrenia based on ANAVEX®3-71’s ability to synergistically activate both SIGMAR1 and M1 muscarinic receptors NEW YORK, Jan. 16, 2024 ...
The anti-xerostomia effects of muscarinic agonists (cholinomimetics) are reviewed. Cevimeline (cevimeline monohydrochloride hemihydrate) is a novel muscarinic agonist that stimulates salivary ...
Early evidence of enhanced brain activity seen at dose levels that are well tolerated Heptares Therapeutics, the clinical-stage GPCR structure-guided drug discovery and development company and ...
SAN FRANCISCO and BOSTON, Sept. 17, 2025 /PRNewswire/ -- MapLight Therapeutics today announced the initiation of a Phase 2 study to evaluate the efficacy, safety and tolerability of ML-007C-MA, an ...
The fine balance between potency and selectivity that looms large in drug development has long stymied efforts to target the M1 muscarinic acetylcholine receptor (mAChR) for treatment of Alzheimer ...
The upfront cash payment is going to Tokyo-based Sosei Heptares. Neurocrine will also fund a research collaboration in which both companies will work together to advance preclinical candidates through ...
Changing patients from an inhaled corticosteroid (ICS)/long-acting β agonist (LABA) inhaler and long-acting muscarinic agonist (LAMA) inhaler to a LAMA/LABA inhaler and a separate ICS inhaler did not ...
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