The development of new therapeutics targeting protein kinases is crucial in the fight against diseases like cancer. Kinase drug discovery programs rely on the precise characterization and screening of ...

Protein kinases are enzymes that transfer a phosphoryl group to serine, threonine, or tyrosine side chains of a target protein, thereby changing its activity. Dysregulation of protein kinases has been ...

In the continuously changing environment of drug development and molecular biology, sensitive and high-throughput kinase activity monitoring remains a key component of target validation and inhibitor ...

In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase ...