In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple ...
Recently discovered electrophilic probes open the door to activity-based protein profiling (ABPP) studies of a broader range of proteins. It can be extremely challenging to study enzymes. Without any ...
New electrophilic reagents for activity-based protein profiling (ABPP) can discriminate between nucleophilic amino acids, such as cysteine, that are in different protein microenvironments. These ...
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