The epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signaling pathway, frequently hyperactivated in CRC, drives tumor growth, but its downstream effectors ...

TRPV1 further promotes a process called secretory autophagy, which leads epidermal growth factor (EGF) secretion. EGF, in turn, activates the EGFR signaling pathway, contributing to cisplatin ...

Furthermore, when the effects of lenvatinib on signal transduction pathways were analyzed in six thyroid cancer cell lines, enhancement of EGFR phosphorylation was observed in all the cell lines ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for developing effective treatments.

The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously described critical components of this ...

Conclusions: Lack of phosphorylation of AKT and lack of PTEN expression in the AKT pathway downstream of EGFR may be a mechanism of MPM's clinical resistance to OSI-774. ERK is variably activated ...