The Week 12 NFL schedule is headlined by the ever-continuing saga of the Kansas City Chiefs against the AFC South-leading Indianapolis Colts on Nov. 23. Kansas City is 5-5 after losing on a last-second field goal at Denver and returns home in need of a run.

SportsLine's computer model reveals its Rams vs. Buccaneers predictions for 'Sunday Night Football' in NFL Week 12

How will Josh Allen's Bills fare against the Texans' ferocious defense tonight? Can the scuffling Chiefs earn a desperately needed win over the Colts? Who prevails in an enticing Sunday night showdown between the Buccaneers and Rams?

The NFL's upcoming lineup of games is rife with questions. But there's little question that the Chiefs are approaching must-win territory in Week 12.

The Cincinnati Bengals won’t activate quarterback Joe Burrow for the Week 12 game against the New England Patriots, according to a new report.

Will the Browns lean on the run in Shedeur Sanders' first start? Will Eagles-Cowboys come down to Jalen Hurts? Is Michael Wilson startable in fantasy?

Ahead of their matchup against the Pittsburgh Steelers on Sunday, the Chicago Bears were showcased on a hype video from NFL on CBS.

DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for the Week 12 NFL DFS main slate