The No. 21 Missouri Tigers (7-3, 3-3 SEC) and No. 8 Oklahoma Sooners (8-2, 4-2) meet Saturday at Memorial Stadium in Norman, Oklahoma. Kickoff is scheduled for noon ET (ABC). Let's analyze BetMGM Sportsbook's NCAA football odds around the Missouri vs. Oklahoma odds and make our expert college football picks and predictions for the best bets.

Oklahoma Sooners wide receiver Isaiah Sategna III (5) warms up before a college football game between the University of Oklahoma Sooners (OU) and the Missouri Tigers at Gaylord Family Ð Oklahoma Memorial Stadium in Norman, Okla., on Saturday, Nov. 22, 2025.

The No. 8 Oklahoma Sooners look to continue their winning ways as the No. 22 Missouri Tigers come to Norman on Saturday.

John Mateer threw two touchdown passes, and No. 8 Oklahoma defeated No. 23 Missouri 17-6 on Saturday to inch closer to a College Football

The Sooners' defense smothered the Tigers on Saturday, pushing OU within one win of returning to the College Football Playoff.

The Missouri Tigers and Oklahoma Sooners will play at 11 a.m. CT on November 22, 2025 at Gaylord Family – Oklahoma Memorial Stadium in Norman. The game will air live on ABC in Week 13 of the college football season. In Nashville, the game can be seen on WKRN (Channel 2).

The Oklahoma Sooners and Missouri Tigers are no strangers, having squared off several times in conference play well before the two universities joined the SEC.

No. 8 Oklahoma can almost taste the College Football Playoff. The Sooners will be favored in each of their final two regular-season games, likely needing to go 2-0 to clinch a spot in the CFP bracket.

Missouri Tigers starting quarterback Beau Pribula is expected to start on Saturday against the Oklahoma Sooners in Norman, just four weeks after suffering a dislocated ankle that many feared would end his 2025 regular season.